Psalm 22
There are around ten psalms classed as Messianic in that they contain prophecies concerning Jesus’ life, ministry or crucifixion. Psalm 22 is probably the most well known as it describes with remarkable accuracy aspects of Jesus’ crucifixion, centuries before this horrific method of execution was invented. This was written by David, the subject matter being suffering and salvation. What follows are the prophetic verses with some comments.
Verse 1: My God, my God, why have You forsaken me....
These are the words cried out by Jesus on the cross. Matt 27:46 And about the ninth hour, Jesus cried with a loud voice, saying, Eli, Eli, lama sabachthani? That is, My God, My God, why have You forsaken me? Mk 15:34 And at the ninth hour Jesus cried with a loud voice, saying, Eloi, Eloi, lama sabachthani? (which being translated is, My God, My God, why did You forsake Me?)
Verses 7 & 8:  All who see Me mock me; they shoot out the lip; they shake the head, saying,  He trusted on Jehovah; let Him deliver Him; let Him rescue Him, since He delights in Him!
These verses describe the abuse Jesus received whilst hanging on the cross, reflected in rthe following: Mat 27:41-44  And in the same way also the chief priests mocked, with the scribes and elders, saying, 42 He saved others, but he cannot save himself. If he is the King of Israel, let him now come down from the cross, and we will believe him. 43 He trusted in God, let Him deliver Him now, if He will have Him. (For He said, I am the Son of God.)  44 And also the thieves who were crucified with Him reviled Him, saying the same. Mar 15:29-32 And those who passed by blasphemed Him, wagging their heads and saying, Aha! You razing the temple and building it in three days,  30  save yourself and come down from the cross! 31  And also the chief priests mocking, with the scribes, said to one another, He saved others but he cannot save himself. 32  Let Christ the King of Israel now come down from the cross, so that we may see and believe. And they who were crucified with Him insulted Him. Lk 23:35-37  And the people stood watching. And also the rulers with them, scoffing, saying, He saved others, let Him save Himself, if He is the Christ, the chosen of God. 36  And coming near, the soldiers also mocked Him, and offering Him sour wine,  37  and saying, If You are the king of the Jews, save Yourself.
Verses 14-17 I am poured out like water, and all My bones are spread apart; My heart is like wax; it is melted in the midst of My bowels. 15 My strength is dried up like a potsherd, and My tongue clings to My jaws;  16 and You have brought Me into the dust of death. For dogs have circled around Me; the band of spoilers have hemmed Me in, piercers of My hands and My feet. 17  I can count all My bones; they look and stare at Me.
These verses describe the agony on the cross. The agony of crucifixion is well documented, but scarcely mentioned in the Gospels, Thomas’ doubt being an example: Jn 20:25 The other disciples therefore said to him, We have seen the Lord. But he [Thomas] said to them, Unless I shall see the print of the nails in His hands, and put my finger into the print of the nails, and thrust my hand into His side, I will not believe.
Verse 18  They divide My garments among them and cast lots for My clothing.
This verse describes the dividing of, and casting lots for, Jesus’ garments, reported in all four Gospels. Matt 27:35 And they crucified Him, dividing His garments, casting a lot; so that it might be fulfilled which was spoken by the prophet, "They parted My garments among them, and they cast a lot for My clothing." Mk 15:24 And when they had crucified Him, they divided His garments, casting lots on them, as, to what each should take. Lk 23:34 And Jesus said, Father, forgive them, for they do not know what they do. And parting His clothing, they cast lots. Jn 19:24; Therefore they said among themselves, Let us not tear it, but cast lots for it to find whose it shall be (that the Scripture might be fulfilled which says, "They parted my garments among them, and for my garment they cast lots"). Therefore the soldiers did these things.
Finally, verses 19-21 But You, O Jehovah, be not far from Me; O My strength, hurry to help Me!  20 Deliver My soul from the sword, My only one from the dog's hand. 21 Save Me from the lion's mouth; from the wild oxen's horns. You have answered Me. 
Verses 19-21 speak of deliverance. Verses 12 & 13 are ‘column’ references where ferocious bulls and lions are mentioned, representing the dangers faced: 12  Many bulls have circled around Me; strong bulls Of Bashan have surrounded Me.  13  They opened wide their mouths on Me, like a ripping and a roaring lion.